Possible effect of mobile phone radiation on the expression of the blood-brain barrier regulatory proteins

Aim of the study

The project examines whether mobile phone radiation affects the expression of proteins involved in the function of blood-brain barrier.

Implementation

Cultures of human endothelial cell line EAhy926 will be used as an experimental model. The cells will be exposed to 1800MHz GSM mobile phone radiation signal. Following exposure, the proteins will be extracted from the cells and separated using an SDS-PAGE. After that, the expression of several proteins involved in functioning of blood-brain barrier (ZO-1, occludin, claudin) will be examined using the Western blot technique.

Dissemination and exploitation of results

The project will determine whether mobile phone radiation has any effect on the expression of blood-brain barrier regulatory proteins. This will allow determining whether mobile phone radiation could or could not affect the function of blood-brain barrier and whether further studies, using in vitro and animal models are justified. Results obtained in the project will be published in a peer-review journal and presented at an international conference.

Collaborators

Swiss Federal Institute of Technology, Zurich, Switzerland (Prof. Niels Kuster)

Timetable

2008

Responsible scientist

Dariusz Leszczynski

Page updated 15/05/2009